Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.78 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.78 |
| ▸ | FYN | P06241 | 1/20 | 0.78 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.74 |
| ▸ | PARP11 | Q9NR21 | 7/20 | 0.74 |
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.62 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
| ▸ | PRF1 | P14222 | 4/20 | 0.53 |
| ▸ | TARS1 | P26639 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264116 | 0.88 | CLK4 (1.00) | CLK4DYRK1BFYNPARP10PARP11 | |
| SCHEMBL8156296 | 0.85 | PARP10 (1.00) | CLK4DYRK1BFYNPARP10PARP11 | |
| SCHEMBL8167297 | 0.83 | CLK4 (0.75) | CLK4DYRK1BFYNPARP10PARP11 | |
| SCHEMBL148819 | 0.81 | PARP10 (0.68) | CLK4DYRK1BFYNPARP10PARP11 | |
| M-Xylene SCHEMBL1782272 | 0.81 | CLK4 (0.56) | CLK4DYRK1BFYNPARP10PARP11 | |
| SCHEMBL10243599 | 0.81 | PARP10 (0.74) | CLK4DYRK1BFYNPARP10PARP11 | |
| M-Xylene SCHEMBL1785614 | 0.80 | CLK4 (0.55) | CLK4DYRK1BFYNPARP10PARP11 | |
| M-Xylene SCHEMBL1784159 | 0.80 | CLK4 (0.55) | CLK4DYRK1BFYNPARP10PARP11 | |
| Ethane SCHEMBL27832823 | 0.80 | PARP10 (0.66) | CLK4DYRK1BFYNPARP10PARP11 | |
| SCHEMBL2017969 | 0.79 | PRF1 (0.64) | CLK4DYRK1BFYNPARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |