Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8137489 | 0.74 | HTR2A (0.54) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL12852526 | 0.71 | HTR2A (0.56) | HTR2AHTR2CDRD2MEN1KMT2A | |
| SCHEMBL28740554 | 0.71 | BRD4 (0.52) | HTR2AHTR2CDRD2KCNH2CHRNB2 | |
| SCHEMBL11893151 | 0.67 | DRD2 (0.65) | HTR2AHTR2CDRD2KCNH2CHRNB2 | |
| SCHEMBL2077235 | 0.67 | DRD2 (0.65) | HTR2AHTR2CDRD2KCNH2CHRNB2 | |
| SCHEMBL13006443 | 0.67 | DRD2 (0.65) | HTR2AHTR2CDRD2KCNH2CHRNB2 | |
| Hydrochloric Acid SCHEMBL11627075 | 0.66 | SLC6A2 (0.54) | HTR2AHTR2CDRD2KCNH2HTR1A | |
| SCHEMBL2277992 | 0.66 | HTR2C (0.48) | HTR2AHTR2CDRD2HTR1AHTR1D | |
| SCHEMBL25722721 | 0.65 | HTR2A (0.59) | HTR2AHTR1AHTR7HTR2B | |
| SCHEMBL8525408 | 0.65 | HTR2A (1.00) | HTR2AHTR2CDRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037876-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | Novartis AG (CH) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999023073-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | NOVARTIS AG (CH) | 1999-05-14 | — | — | WO | disclosed |