Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19737045 | 0.93 | HMGCR (0.62) | HMGCRALOX5GABRA1GABRB2TAAR1 | |
| SCHEMBL11793593 | 0.83 | HMGCR (0.81) | HMGCRALOX5GABRA1GABRB2TAAR1 | |
| SCHEMBL1276493 | 0.81 | HMGCR (1.00) | HMGCRALOX5GABRA1GABRB2 | |
| SCHEMBL15356820 | 0.80 | HMGCR (0.65) | HMGCRALOX5GABRA1GABRB2TAAR1 | |
| SCHEMBL8614276 | 0.79 | HMGCR (0.47) | HMGCRALOX5 | |
| Hydrochloric Acid SCHEMBL20510648 | 0.79 | TAAR1 (0.45) | HMGCRTAAR1HTR2AHTR2C | |
| SCHEMBL11392839 | 0.76 | HMGCR (0.52) | HMGCRALOX5TAAR1 | |
| SCHEMBL8155803 | 0.76 | ALOX5 (0.49) | HMGCRALOX5GABRA1GABRB2 | |
| SCHEMBL8156668 | 0.76 | HMGCR (0.46) | HMGCRTAAR1HTR2A | |
| SCHEMBL24445889 | 0.74 | HMGCR (0.45) | HMGCRTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686145-B1 | NEW COMPOUNDS | UNIV MARYLAND (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5883129-A | Hydroxylated anthranilic acid derivatives | ASTRA AKTIEBOLAG (SE) | 1999-03-16 | — | — | US | disclosed |
| US-5523475-A | New compounds | AKTIEBOLAGET ASTRA (SE) | 1996-06-04 | — | — | US | disclosed |
| EP-0686145-A1 | NEW COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019316-A1 | NEW COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1994-09-01 | — | — | WO | disclosed |