Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.55 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL29061402 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL2100969 | 0.94 | — | — | |
| Bicarbonate SCHEMBL222994 | 0.94 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1332486 | 0.94 | — | — | |
| Bicarbonate SCHEMBL15321596 | 0.94 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL83 | 0.94 | — | — | |
| Bicarbonate SCHEMBL10646323 | 0.94 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1332636 | 0.94 | — | — | |
| Bicarbonate SCHEMBL5403678 | 0.94 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL9638573 | 0.94 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979034-A1 | COMPOSITION FOR CONTROLLING HARMFUL BIO-ORGANISMS AND METHOD FOR CONTROLLING HARMFUL BIO-ORGANISMS USING THE SAME | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998048628-A1 | COMPOSITION FOR CONTROLLING HARMFUL BIO-ORGANISMS AND METHOD FOR CONTROLLING HARMFUL BIO-ORGANISMS USING THE SAME | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1998-11-05 | — | — | WO | disclosed |