SCHEMBL8157652

SCHEMBL8157652

O=c1ccn2c3ccc(Br)cc3c3cc(OCc4ncon4)cc1c32

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.34
MAOB P27338 2/20 0.34
PIK3R1 P27986 1/20 0.31
PIK3CA P42336 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8157787 0.80 MAOB (0.44) MAOAMAOB
SCHEMBL6983135 0.77 PTGDR2 (0.39)
SCHEMBL6978806 0.77 GRM2 (0.41) MAOAMAOB
SCHEMBL6983094 0.76 MAOB (0.33) MAOAMAOBPIK3R1PIK3CA
SCHEMBL7087746 0.76 MAOA (0.33) MAOAMAOB
SCHEMBL7083107 0.75 IDO1 (0.33) MAOAMAOB
SCHEMBL6982438 0.75 PIK3R1 (0.39) PIK3R1PIK3CA
SCHEMBL6978232 0.73 CHEK1 (0.36)
SCHEMBL6979976 0.73 SMN1; SMN2 (0.34) PIK3R1PIK3CA
SCHEMBL6976234 0.72 NPC1 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0992240-A1 THERAPEUTIC AGENT FOR ERECTION FAILURE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-04-12 EP disclosed