Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9295296 | 0.86 | KDM1A (0.56) | PREPACE2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9295289 | 0.86 | KDM1A (0.56) | PREPACE2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9295294 | 0.86 | KDM1A (0.56) | PREPACE2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27766855 | 0.85 | PREP (0.56) | PREPACE2HSD17B10NPC1RAB9A | |
| SCHEMBL27495021 | 0.84 | PREP (0.50) | PREPACE2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3011829 | 0.83 | PREP (0.56) | PREPACE2HSD17B10NPC1RAB9A | |
| SCHEMBL10310512 | 0.83 | PREP (0.56) | PREPACE2HSD17B10NPC1RAB9A | |
| SCHEMBL1875019 | 0.83 | PREP (0.54) | PREPACE2HSD17B10NPC1RAB9A | |
| SCHEMBL16857371 | 0.83 | SMN1; SMN2 (0.54) | PREPACE2HSD17B10NPC1RAB9A | |
| SCHEMBL9200215 | 0.82 | RAB9A (0.55) | PREPACE2RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071927-A | Spiro-piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2000-06-06 | — | — | US | disclosed |