Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8157683 | 0.82 | PREP (0.53) | RAB9ATSHRACE2PREP | |
| SCHEMBL8059786 | 0.82 | CHRM2 (0.46) | TSHRACE2HCRTR2RIPK1PRMT5 | |
| SCHEMBL9274408 | 0.82 | CHRM2 (0.46) | TSHRACE2HCRTR2RIPK1PRMT5 | |
| SCHEMBL9024840 | 0.79 | RIPK1 (0.52) | TSHRALDH1A1HCRTR2RIPK1 | |
| SCHEMBL9025059 | 0.79 | RIPK1 (0.52) | TSHRALDH1A1HCRTR2RIPK1 | |
| SCHEMBL5784217 | 0.79 | RIPK1 (0.52) | TSHRALDH1A1HCRTR2RIPK1 | |
| SCHEMBL8125588 | 0.79 | RIPK1 (0.52) | TSHRALDH1A1HCRTR2RIPK1 | |
| SCHEMBL9023721 | 0.79 | RIPK1 (0.52) | TSHRALDH1A1HCRTR2RIPK1 | |
| SCHEMBL8121365 | 0.79 | RIPK1 (0.52) | TSHRALDH1A1HCRTR2RIPK1 | |
| SCHEMBL5968844 | 0.77 | RIPK1 (0.51) | TSHRALDH1A1RIPK1DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636130-A1 | AZACYCLIC COMPOUNDS | MERCK SHARP & DOHME LTD. (GB) | 1995-02-01 | — | — | EP | disclosed |