Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 17/20 | 0.46 |
| ▸ | AURKA | O14965 | 14/20 | 0.46 |
| ▸ | MET | P08581 | 14/20 | 0.46 |
| ▸ | TEK | Q02763 | 14/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.46 |
| ▸ | LCK | P06239 | 10/20 | 0.46 |
| ▸ | LYN | P07948 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | FGR | P09769 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | PDXK | O00764 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8164387 | 0.89 | RXRA (0.46) | KDRAURKAMETTEKAURKB | |
| SCHEMBL8165775 | 0.88 | RXRA (0.53) | PDE4BKDRAURKAMETTEK | |
| SCHEMBL8158825 | 0.85 | PDE4B (0.56) | PDE4BKDRAURKAMETTEK | |
| SCHEMBL8014653 | 0.78 | RXRA (0.55) | RXRA | |
| SCHEMBL8170768 | 0.77 | RXRA (0.61) | KDRAURKAMETTEKAURKB | |
| SCHEMBL8165528 | 0.76 | PDE4B (0.43) | PDE4BKDRAURKAMETTEK | |
| SCHEMBL6372600 | 0.74 | RXRA (0.60) | RXRA | |
| SCHEMBL8165505 | 0.74 | RXRA (0.60) | PDE4BRXRA | |
| SCHEMBL2237855 | 0.73 | MTNR1A (0.56) | PDE4BKDRAURKAMETTEK | |
| SCHEMBL8165276 | 0.73 | RXRA (0.52) | PDE4BKDRAURKAMETTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156750-A | Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-05 | — | — | US | disclosed |
| US-5985928-A | HUMAN OR VETERINARY MEDICINE FOR EXAMPLE DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5763487-A | SKIN DISORDERS, CARDIOVASCULAR DISORDERS AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-06-09 | — | — | US | disclosed |
| EP-0722928-B1 | Bicyclic-aromatic compounds with strong biologic activity, pharmaceutical and cosmetic compositions containing them and uses thereof | CIRD GALDERMA (FR) | 1997-08-06 | — | — | EP | disclosed |
| EP-0722928-A1 | Bicyclic-aromatic compounds with strong biologic activity, pharmaceutical and cosmetic compositions containing them and uses thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1996-07-24 | — | — | EP | disclosed |