Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.63 |
| ▸ | RXRB | P28702 | 6/20 | 0.63 |
| ▸ | RXRG | P48443 | 6/20 | 0.63 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.46 |
| ▸ | RARG | P13631 | 4/20 | 0.42 |
| ▸ | RARA | P10276 | 3/20 | 0.42 |
| ▸ | RARB | P10826 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8157754 | 0.86 | CYP26B1 (0.53) | RXRARXRBRXRGCYP26A1RARG | |
| SCHEMBL8170066 | 0.83 | RXRA (0.48) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL8170768 | 0.78 | RXRA (0.61) | RXRARXRBRXRGCYP26A1RARG | |
| SCHEMBL8894039 | 0.78 | RXRA (1.00) | RXRARXRBRXRGCYP26A1RARG | |
| SCHEMBL8158842 | 0.76 | RXRA (0.63) | RXRARXRBRXRGCYP26A1RARG | |
| SCHEMBL8165505 | 0.75 | RXRA (0.60) | RXRARXRBRXRGCYP26A1RARG | |
| SCHEMBL8164812 | 0.74 | RARB (0.49) | RXRARXRBRXRGCYP26A1RARG | |
| SCHEMBL8166267 | 0.72 | RARB (0.62) | RXRARXRBRXRGCYP26A1RARG | |
| SCHEMBL8165171 | 0.72 | RARB (0.48) | RXRARXRBRXRGCYP26A1RARG | |
| SCHEMBL8164387 | 0.70 | RXRA (0.46) | RXRARXRBRXRGRARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722928-B1 | Bicyclic-aromatic compounds with strong biologic activity, pharmaceutical and cosmetic compositions containing them and uses thereof | CIRD GALDERMA (FR) | 1997-08-06 | — | — | EP | claimed |
| US-6156750-A | Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-05 | — | — | US | disclosed |
| US-5985928-A | HUMAN OR VETERINARY MEDICINE FOR EXAMPLE DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5763487-A | SKIN DISORDERS, CARDIOVASCULAR DISORDERS AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-06-09 | — | — | US | disclosed |