Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.53 |
| ▸ | RARB | P10826 | 11/20 | 0.46 |
| ▸ | RARA | P10276 | 9/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 6/20 | 0.44 |
| ▸ | RXRB | P28702 | 5/20 | 0.44 |
| ▸ | RXRG | P48443 | 4/20 | 0.44 |
| ▸ | RARG | P13631 | 10/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8158237 | 0.86 | RXRA (0.63) | CYP26B1RARBRARAPTPN1RXRA | |
| SCHEMBL8165505 | 0.83 | RXRA (0.60) | CYP26B1RARBRARAPTPN1RXRA | |
| SCHEMBL8165760 | 0.82 | CYP26B1 (0.45) | CYP26B1RXRARXRBRXRGCYP26A1 | |
| SCHEMBL8164812 | 0.82 | RARB (0.49) | CYP26B1RARBRARAPTPN1RXRA | |
| SCHEMBL8166267 | 0.81 | RARB (0.62) | CYP26B1RARBRARAPTPN1RXRA | |
| SCHEMBL8165171 | 0.80 | RARB (0.48) | CYP26B1RARBRARAPTPN1RXRA | |
| SCHEMBL5680234 | 0.78 | RARB (0.69) | CYP26B1RARBRARARXRARXRB | |
| SCHEMBL7723491 | 0.77 | RXRA (0.69) | CYP26B1RARBRARARXRARXRB | |
| SCHEMBL9051406 | 0.75 | RARB (0.68) | CYP26B1RARBRARAPTPN1RXRA | |
| SCHEMBL31191789 | 0.75 | RARB (0.68) | CYP26B1RARBRARAPTPN1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722928-B1 | Bicyclic-aromatic compounds with strong biologic activity, pharmaceutical and cosmetic compositions containing them and uses thereof | CIRD GALDERMA (FR) | 1997-08-06 | — | — | EP | claimed |
| US-6156750-A | Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-05 | — | — | US | disclosed |
| US-5985928-A | HUMAN OR VETERINARY MEDICINE FOR EXAMPLE DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5763487-A | SKIN DISORDERS, CARDIOVASCULAR DISORDERS AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-06-09 | — | — | US | disclosed |