Teprotide

SCHEMBL8158703

CCC(C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O.C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Teprotide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	CXCR4	P61073	2/20	0.51

▸	F13A1	P00488	2/20	0.49

▸	TGM2	P21980	2/20	0.49

▸	IL23R	Q5VWK5	1/20	0.48

▸	APLNR	P35414	1/20	0.48

▸	ABCC2	Q92887	1/20	0.47

▸	GNRHR	P30968	1/20	0.47

▸	PTGS1	P23219	1/20	0.46

▸	CTNNB1	P35222	1/20	0.46

▸	CTSL	P07711	2/20	0.46

▸	CTSS	P25774	2/20	0.46

▸	CTSK	P43235	2/20	0.46

▸	CTSH	P09668	1/20	0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Teprotide SCHEMBL11855843	0.97	F13A1 (0.52)	CXCR4F13A1TGM2IL23RAPLNR
Teprotide SCHEMBL613590	0.97	F13A1 (0.52)	CXCR4F13A1TGM2IL23RAPLNR
SCHEMBL11872216	0.93	GNRHR (0.50)	CXCR4F13A1TGM2APLNRABCC2
SCHEMBL11867492	0.91	GNRHR (0.51)	CXCR4F13A1TGM2IL23RAPLNR
Teprotide SCHEMBL613757	0.88	GNRHR (0.57)	F13A1TGM2APLNRABCC2GNRHR
SCHEMBL11863142	0.86	IL23R (0.51)	CXCR4F13A1TGM2IL23RCTNNB1
SCHEMBL11863118	0.86	IL23R (0.51)	CXCR4F13A1TGM2IL23RCTNNB1
SCHEMBL11865471	0.84	CXCR4 (0.46)	CXCR4F13A1TGM2IL23RAPLNR
SCHEMBL24120770	0.84	CXCR4 (0.55)	CXCR4CTNNB1CTSLCTSSCTSK
SCHEMBL11872436	0.83	CASP1 (0.51)	CXCR4IL23RCTNNB1CTSLCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0841917-A4	METHOD OF TREATMENT FOR EXERCISE-INDUCED PULMONARY HEMORRHAGE IN RACING STOCK	PANTANO JAMES A (US)	2000-05-17	—	—	EP	disclosed
EP-0841917-A1	METHOD OF TREATMENT FOR EXERCISE-INDUCED PULMONARY HEMORRHAGE IN RACING STOCK	Pantano, James A. (US)	1998-05-20	—	—	EP	disclosed
WO-1997009041-A1	METHOD OF TREATMENT FOR EIPH IN RACING STOCK	PANTANO JAMES A (US)	1997-03-13	—	—	WO	disclosed