Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.37 |
| ▸ | PPARA | Q07869 | 8/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ACP3 | P15309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951687 | 0.85 | HTR7 (0.39) | PPARGPPARAACHEHTR7HTR1A | |
| SCHEMBL5951730 | 0.83 | ACHE (0.45) | ACHEHTR7HTR1AMAPTMAPK1 | |
| SCHEMBL5951450 | 0.82 | METAP1 (0.41) | ACHEHTR7HTR1A | |
| SCHEMBL5951618 | 0.79 | ACHE (0.48) | ACHEADRB3GPR183GRM2HTR7 | |
| SCHEMBL3078503 | 0.75 | ACHE (0.48) | ACHEHTR7HTR1AATMACP3 | |
| SCHEMBL8161364 | 0.75 | ACHE (0.39) | PPARGPPARAACHEHTR7HTR1A | |
| SCHEMBL5953322 | 0.73 | HTR7 (0.43) | ACHEHTR7HTR1AMAPT | |
| SCHEMBL5953305 | 0.71 | HTR7 (0.44) | ACHEHTR7HTR1AMAPT | |
| SCHEMBL5951597 | 0.69 | MAPT (0.41) | ACHEHTR7HTR1AMAPT | |
| SCHEMBL5951507 | 0.69 | ACHE (0.43) | ACHEHTR7HTR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968158-A1 | METHOD OF PREPARING SUBSTITUTED INDANONES, THE SUBSTITUTED INDANONES AND METALLOCENES PREPARED THEREFROM | Basell Polyolefine GmbH (DE) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998040331-A1 | PREPARATION OF PREPARING SUBSTITUTED INDANONES | TARGOR GMBH (DE) | 1998-09-17 | — | — | WO | disclosed |