SCHEMBL8159092

SCHEMBL8159092

CCCCNc1ccc(C)c(N)c1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.49
ABL1 P00519 1/20 0.44
TLR8 Q9NR97 6/20 0.42
HTT P42858 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CASP1 P29466 1/20 0.41
BACE1 P56817 1/20 0.40
AR P10275 1/20 0.40
SKP2 Q13309 1/20 0.40
CYP3A4 P08684 1/20 0.38
F2R P25116 1/20 0.37
TLR7 Q9NYK1 1/20 0.37
MAPT P10636 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29262271 0.93 ABL1 (0.53) ALDH1A1ABL1TLR8HTTTDP1
SCHEMBL15928722 0.89 ALDH1A1 (0.43) ALDH1A1ABL1HTTTDP1CASP1
SCHEMBL2455817 0.86 ALDH1A1 (0.49) ALDH1A1HTTTDP1CASP1CYP3A4
SCHEMBL10394666 0.83 ALDH1A1 (0.68) ALDH1A1ABL1HTTTDP1AR
SCHEMBL6228833 0.81 ALDH1A1 (0.71) ALDH1A1ABL1HTTTDP1CASP1
SCHEMBL6227906 0.81 ALDH1A1 (0.71) ALDH1A1ABL1HTTTDP1CASP1
SCHEMBL5012623 0.81 ALDH1A1 (0.46) ALDH1A1HTTTDP1CASP1CYP3A4
SCHEMBL11798071 0.80 ALDH1A1 (0.54) ALDH1A1ABL1TLR8HTTBACE1
SCHEMBL11443275 0.80 ALDH1A1 (0.54) ALDH1A1HTTTDP1CASP1CYP3A4
SCHEMBL26325050 0.80 ALDH1A1 (0.50) ALDH1A1ABL1HTTBACE1AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000073368-A1 COMPOSITION FOR USE IN FLEXIBLE POLYURETHANE FOAMS SOLUTIA INC. (US) 2000-12-07 WO disclosed