SCHEMBL8159673

SCHEMBL8159673

CCCCCCCCCCCC(=S)Nc1c(C)cc(C)cc1OCCCC(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.47
S1PR5 Q9H228 2/20 0.41
ALDH1A1 P00352 4/20 0.41
FABP4 P15090 3/20 0.41
SOAT1 P35610 1/20 0.41
POLB P06746 1/20 0.41
HPGD P15428 1/20 0.41
KDM4E B2RXH2 1/20 0.40
GPR84 Q9NQS5 6/20 0.40
PPARG P37231 6/20 0.40
PPARD Q03181 6/20 0.40
PPARA Q07869 6/20 0.40
HDAC11 Q96DB2 5/20 0.40
TLR2 O60603 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
PTPN1 P18031 2/20 0.40
SLC22A6 Q4U2R8 1/20 0.40
SLC22A8 Q8TCC7 1/20 0.40
MEN1 O00255 1/20 0.40
ESR1 P03372 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8150227 0.83 TSHR (0.54) TSHRALDH1A1POLBHPGDKDM4E
SCHEMBL8162170 0.81 TSHR (0.53) TSHRS1PR5ALDH1A1KDM4ETDP1
SCHEMBL8157553 0.81 GAA (0.56) TSHRS1PR5ALDH1A1KDM4EPPARG
SCHEMBL8156126 0.76 ALDH1A1 (0.53) TSHRALDH1A1POLBPTPN1MEN1
SCHEMBL8150254 0.76 ALDH1A1 (0.53) TSHRALDH1A1POLBPTPN1MEN1
SCHEMBL8158408 0.76 ALDH1A1 (0.53) TSHRALDH1A1POLBPTPN1MEN1
SCHEMBL8151178 0.74 PTPN1 (0.54) TSHRALDH1A1POLBPPARGPTPN1
SCHEMBL8158316 0.73 L3MBTL1 (0.41) TSHRALDH1A1TDP1PTPN1MEN1
SCHEMBL8163921 0.73 MAPT (0.49) TSHRS1PR5ALDH1A1PPARGPPARD
SCHEMBL8158326 0.73 ALDH1A1 (0.45) ALDH1A1HPGDKDM4EPPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6046183-A SYNERGISTIC MIXTURE OF FINASTERIDE AND DOXAZOSIN MERCK & CO., INC. (US) 2000-04-04 US disclosed
US-5994362-A ADMINISTERING FINASTERIDE AND CASODEX MERCK & CO., INC. (US) 1999-11-30 US disclosed
US-5753641-A SYNERGISTIC THERAPY COMPRISING FINASTERIDE AND TERAZOSIN DRUGS MERCK & CO., INC. (US) 1998-05-19 US disclosed
EP-0576603-A1 PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC HYPERPLASIA, CONTAINING A 5 ALPHA-REDUCTASE INHIBITOR AND AN ANTIANDROGEN MERCK & CO. INC. (US) 1994-01-05 EP disclosed
EP-0525885-A1 New sulphur containing nonsteroidal drugs as 5-alpha reductase inhibitors MERCK & CO. INC. (US) 1993-02-03 EP disclosed
WO-1992018132-A1 PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA COMTAINING A 5 ALPHA-REDUCTASE INHIBITOR MERCK & CO., INC. (US) 1992-10-29 WO disclosed
WO-1992016213-A1 PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC HYPERPLASIA, CONTAINING A 5 ALPHA-REDUCTASE INHIBITOR AND AN ANTIANDROGEN MERCK & CO., INC. (US) 1992-10-01 WO disclosed
WO-1992016233-A1 PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN MERCK & CO., INC. (US) 1992-10-01 WO disclosed