SCHEMBL8159891

SCHEMBL8159891

CC(C)(C(=O)C(C)(C)c1cccc(Cl)c1)c1cccc(Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN5A Q14524 3/20 0.44
SCN9A Q15858 3/20 0.44
SLC6A2 P23975 2/20 0.42
CHRNA1 P02708 1/20 0.42
CHRNG P07510 1/20 0.42
ITGA5 P08648 1/20 0.42
CHRNB1 P11230 1/20 0.42
CHRNB2 P17787 1/20 0.42
CHRNB4 P30926 1/20 0.42
SLC6A4 P31645 1/20 0.42
CHRNA3 P32297 1/20 0.42
CYP2C19 P33261 1/20 0.42
HRH1 P35367 1/20 0.42
CHRNA7 P36544 1/20 0.42
OPRK1 P41145 1/20 0.42
CHRNA4 P43681 1/20 0.42
SLC6A3 Q01959 1/20 0.42
CHRND Q07001 1/20 0.42
KCNH2 Q12809 1/20 0.42
PARP1 P09874 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL602646 0.86 SCN5A (0.43) SCN5ASCN9ASLC6A2CHRNA1CHRNG
SCHEMBL1628254 0.86 AKR1C3 (0.50) SCN5ASCN9ASLC6A2CHRNA1CHRNG
SCHEMBL1203861 0.86 SCN5A (0.43) SCN5ASCN9ASLC6A2CHRNA1CHRNG
SCHEMBL11541397 0.85 MAPT (0.60) SCN5ASCN9ASLC6A2CHRNA1CHRNG
SCHEMBL6670810 0.83 KIF11 (0.42) SCN5ASCN9ASLC6A2CHRNA1CHRNG
SCHEMBL11017565 0.82 CNR2 (0.47) SCN5ASCN9ASLC6A2CHRNA1CHRNG
SCHEMBL25008509 0.80 VNN1 (0.48) SLC6A2CHRNA1CHRNGITGA5CHRNB1
SCHEMBL11003865 0.80 SCN5A (0.43) SCN5ASCN9ASLC6A2CHRNA1CHRNG
SCHEMBL3942185 0.77 SCN5A (0.46) SCN5ASCN9ASLC6A2CHRNA1CHRNG
SCHEMBL30927959 0.77 SCN5A (0.46) SCN5ASCN9ASLC6A2CHRNA1CHRNG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000075094-A2 METHOD FOR PRODUCING A HALOGENATED ACETOPHENONE ISHIHARA SANGYO KAISHA, LTD. (JP) 2000-12-14 WO disclosed