Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153727 | 0.85 | METAP1 (0.40) | METAP1ACHEALDH1A1CYP19A1SMN1; SMN2 | |
| SCHEMBL7302832 | 0.83 | GAA (0.38) | MAPTMAPK1GAAALDH1A1KDM4E | |
| SCHEMBL8745482 | 0.80 | METAP1 (0.44) | METAP1ACHECYP19A1 | |
| SCHEMBL7296622 | 0.80 | GAA (0.36) | MAPK1GAAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7305086 | 0.79 | ADRA1D (0.39) | MAPK1GAAKDM4EHSD17B10 | |
| SCHEMBL7302057 | 0.79 | ADRA1D (0.39) | MAPK1GAAKDM4EHSD17B10 | |
| SCHEMBL7296333 | 0.79 | ADRA1D (0.39) | MAPK1GAAKDM4EHSD17B10 | |
| SCHEMBL8160593 | 0.76 | PREP (0.40) | METAP1ACHE | |
| SCHEMBL7737589 | 0.74 | METAP1 (0.52) | METAP1MAPTMAPK1ATMACHE | |
| SCHEMBL7303125 | 0.73 | PREP (0.35) | MAPK1ACHEALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017929-A | Cholinesterase activator | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-25 | — | — | US | disclosed |
| EP-0754454-A1 | CHOLINESTERASE ACTIVATOR | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-22 | — | — | EP | disclosed |