Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28522885 | 0.86 | METAP1 (0.50) | METAP1ACHEMAPTMAPK1ATM | |
| SCHEMBL9258663 | 0.86 | METAP1 (0.52) | METAP1ACHEMAPTMAPK1ATM | |
| SCHEMBL31374607 | 0.85 | METAP1 (0.55) | METAP1ACHECYP19A1HTR1ADRD2 | |
| SCHEMBL9938389 | 0.85 | METAP1 (0.55) | METAP1ACHECYP19A1HTR1ADRD2 | |
| SCHEMBL467497 | 0.84 | ALDH1A1 (0.47) | CYP1A2ACHEMAPTMAPK1ATM | |
| SCHEMBL19984866 | 0.81 | CYP1A2 (0.49) | CYP1A2ATMGAAHSD17B10 | |
| SCHEMBL6273185 | 0.80 | METAP1 (0.59) | METAP1ACHECYP19A1HTR1ADRD2 | |
| SCHEMBL9854934 | 0.80 | METAP1 (0.60) | METAP1ACHECYP19A1 | |
| SCHEMBL7738037 | 0.80 | CYP1A2 (0.41) | METAP1CYP1A2MAPTMAPK1ATM | |
| SCHEMBL11200246 | 0.80 | CYP1A2 (0.49) | CYP1A2MAPTMAPK1ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699909-B1 | MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS | PRESCIENT NEUROPHARMA INC. (CA) | 2004-03-02 | — | — | US | disclosed |
| US-3995052-A | Indenopyran- and indenothiopyranalkylamines III in the treatment of depression | AYERST MCKENNA AND HARRISON LTD. (CA) | 1976-11-30 | — | — | US | disclosed |