Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LIG1 | P18858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11620607 | 0.81 | MEN1 (0.53) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL10526764 | 0.81 | PTPN1 (0.49) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL8165414 | 0.79 | ESR1 (0.52) | MEN1KMT2ANPC1RAB9AHPGD | |
| SCHEMBL8153524 | 0.77 | KMT2A (0.46) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL11621961 | 0.77 | MEN1 (0.55) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL8161985 | 0.76 | CNR2 (0.47) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL8160628 | 0.75 | MMP2 (0.47) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL8154037 | 0.73 | KMT2A (0.43) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL8160356 | 0.73 | SLC22A12 (0.48) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL93420 | 0.71 | MEN1 (0.78) | MEN1KMT2AUSP2GAAKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107346-A | ADMINISTERING AND AROMATIC KETONE COMPOUND | ELI LILLY AND COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0897903-A2 | Ketone-derivatives of indene, dihydronaphthalene or naphthalene compounds for the treatment of hyperlipidemia | ELI LILLY AND COMPANY (US) | 1999-02-24 | — | — | EP | disclosed |