Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165414 | 0.86 | ESR1 (0.52) | CNR2CNR1HSD17B1HSD17B2KMT2A | |
| SCHEMBL11620607 | 0.85 | MEN1 (0.53) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11621961 | 0.81 | MEN1 (0.55) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9301900 | 0.81 | HSD17B1 (0.43) | CNR2CNR1HSD17B1HSD17B2CYP1A2 | |
| SCHEMBL8160039 | 0.80 | CLK1 (0.50) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8153524 | 0.77 | KMT2A (0.46) | CYP3A4KMT2AESR1NPC1RAB9A | |
| SCHEMBL8339441 | 0.76 | CNR2 (0.59) | CNR2CNR1HSD17B1HSD17B2KMT2A | |
| SCHEMBL8160201 | 0.76 | MEN1 (0.44) | KMT2AESR1NPC1RAB9AMEN1 | |
| SCHEMBL8338455 | 0.74 | ESR1 (0.66) | CNR2CNR1HSD17B1HSD17B2ESR1 | |
| SCHEMBL8160628 | 0.72 | MMP2 (0.47) | CYP3A4KMT2AESR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107346-A | ADMINISTERING AND AROMATIC KETONE COMPOUND | ELI LILLY AND COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0897903-A2 | Ketone-derivatives of indene, dihydronaphthalene or naphthalene compounds for the treatment of hyperlipidemia | ELI LILLY AND COMPANY (US) | 1999-02-24 | — | — | EP | disclosed |
| WO-1999007360-A1 | COMPOUNDS AND USES THEREOF | ELI LILLY AND COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |