Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.75 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.75 |
| ▸ | FLT3 | P36888 | 2/20 | 0.75 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.75 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.75 |
| ▸ | PIM1 | P11309 | 1/20 | 0.75 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.75 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | MST1R | Q04912 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 4/20 | 0.51 |
| ▸ | PRF1 | P14222 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14847349 | 0.82 | GSK3B (0.68) | GSK3BNTRK1FLT3CLK4DAPK3 | |
| SCHEMBL10243599 | 0.81 | PARP10 (0.74) | GSK3BNTRK1FLT3CLK4DAPK3 | |
| SCHEMBL504639 | 0.80 | GRM5 (0.76) | GSK3BNTRK1FLT3CLK4DAPK3 | |
| SCHEMBL8167297 | 0.79 | CLK4 (0.75) | GSK3BNTRK1FLT3CLK4DAPK3 | |
| SCHEMBL8163192 | 0.78 | CLK4 (0.59) | GSK3BNTRK1FLT3CLK4DAPK3 | |
| SCHEMBL14847333 | 0.77 | GSK3B (0.58) | GSK3BNTRK1FLT3CLK4DAPK3 | |
| SCHEMBL164795 | 0.77 | GRM5 (0.68) | GSK3BNTRK1FLT3CLK4DAPK3 | |
| SCHEMBL30545957 | 0.77 | GRM5 (0.68) | GSK3BNTRK1FLT3CLK4DAPK3 | |
| SCHEMBL1079809 | 0.76 | CLK4 (0.51) | GSK3BNTRK1FLT3CLK4DAPK3 | |
| SCHEMBL2014718 | 0.75 | PRF1 (0.61) | GSK3BNTRK1FLT3CLK4DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |