Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.75 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.75 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.75 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.75 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.71 |
| ▸ | PARP11 | Q9NR21 | 5/20 | 0.71 |
| ▸ | TDP2 | O95551 | 3/20 | 0.63 |
| ▸ | GSK3B | P49841 | 3/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | PRF1 | P14222 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723086 | 0.86 | CLK4 (1.00) | CLK4NTRK2DYRK1BTYRO3PARP10 | |
| SCHEMBL13680532 | 0.83 | CLK4 (0.78) | CLK4NTRK2DYRK1BTYRO3PARP10 | |
| SCHEMBL10243599 | 0.83 | PARP10 (0.74) | CLK4NTRK2DYRK1BTYRO3PARP10 | |
| SCHEMBL8155722 | 0.83 | PARP11 (1.00) | CLK4NTRK2DYRK1BTYRO3PARP10 | |
| SCHEMBL2014718 | 0.81 | PRF1 (0.61) | CLK4NTRK2DYRK1BTYRO3PARP10 | |
| SCHEMBL2017969 | 0.81 | PRF1 (0.64) | CLK4NTRK2DYRK1BTYRO3PARP10 | |
| SCHEMBL25292799 | 0.80 | PARP11 (0.82) | CLK4NTRK2DYRK1BTYRO3PARP10 | |
| SCHEMBL14847348 | 0.80 | CLK4 (0.51) | CLK4NTRK2DYRK1BTYRO3PARP10 | |
| SCHEMBL8163189 | 0.79 | GSK3B (0.75) | CLK4NTRK2DYRK1BTYRO3PARP10 | |
| SCHEMBL18010841 | 0.77 | TDP2 (1.00) | TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | claimed |
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | DONG-A ST CO., LTD. (KR) | 2025-03-04 | — | — | US | disclosed |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | disclosed |
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | EIF2AK4, GCN1, GCGR | CLK4 3903/4885NTRK2 4356/4885DYRK1B 4797/4885 |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EIF2AK4, GCN1, GCGR | CLK4 3903/4885NTRK2 4356/4885DYRK1B 4797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.