Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.74 |
| ▸ | PARP11 | Q9NR21 | 5/20 | 0.74 |
| ▸ | GRM5 | P41594 | 4/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.62 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.54 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PRF1 | P14222 | 3/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TARS1 | P26639 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8167297 | 0.83 | CLK4 (0.75) | PARP10PARP11GRM5CLK4GSK3B | |
| SCHEMBL30545957 | 0.81 | GRM5 (0.68) | PARP10PARP11GRM5CLK4GSK3B | |
| SCHEMBL164795 | 0.81 | GRM5 (0.68) | PARP10PARP11GRM5CLK4GSK3B | |
| SCHEMBL13680532 | 0.81 | CLK4 (0.78) | PARP10PARP11GRM5CLK4GSK3B | |
| SCHEMBL8163189 | 0.81 | GSK3B (0.75) | PARP10PARP11GRM5CLK4GSK3B | |
| SCHEMBL14847348 | 0.81 | CLK4 (0.51) | PARP10PARP11GRM5CLK4GSK3B | |
| SCHEMBL14847350 | 0.80 | GSK3B (0.54) | PARP10PARP11GRM5CLK4GSK3B | |
| SCHEMBL2017969 | 0.79 | PRF1 (0.64) | PARP10PARP11GRM5CLK4GSK3B | |
| SCHEMBL8163192 | 0.79 | CLK4 (0.59) | PARP10PARP11GRM5CLK4GSK3B | |
| SCHEMBL505100 | 0.78 | GRM5 (1.00) | PARP10PARP11GRM5CLK4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028955-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2012-02-02 | — | — | US | disclosed |
| US-20120028956-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2012-02-02 | — | — | US | disclosed |
| US-8034806-B2 | Bicyclic mGluR5 positive allosteric modulators and methods of making and using same | VANDERBILT UNIVERSITY (US) | 2011-10-11 | — | — | US | disclosed |
| US-20090270362-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028955-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM1 | PARP10 2146/4885PARP11 3085/4885GRM5 1/4885 |
| US-20120028956-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM1 | PARP10 2146/4885PARP11 3085/4885GRM5 1/4885 |
| US-20090270362-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM1 | PARP10 2146/4885PARP11 3085/4885GRM5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.