SCHEMBL8166608

SCHEMBL8166608

CCOC(=O)C(C=O)(CCC(C)C)C(C)C

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 1/20 0.38
HTT P42858 2/20 0.36
HPGD P15428 1/20 0.36
PKM P14618 3/20 0.35
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
CYP4F2 P78329 2/20 0.33
CYP4A11 Q02928 2/20 0.33
THRB P10828 1/20 0.33
KDM4E B2RXH2 1/20 0.31
MAPT P10636 1/20 0.30
ATM Q13315 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8163950 0.83 TDP1 (0.44) MAPT
SCHEMBL335263 0.78 MMP8 (0.42) MMP8HTTHPGDPKMMEN1
SCHEMBL234332 0.75 MMP8 (0.42) MMP8HTTHPGDPKMMEN1
SCHEMBL234357 0.74 MEN1 (0.53) MMP8HTTHPGDPKMMEN1
SCHEMBL7631636 0.74 MMP8 (0.45) MMP8HTTHPGDPKMMEN1
SCHEMBL334816 0.73 MMP8 (0.56) MMP8HTTHPGDPKMMEN1
SCHEMBL28308253 0.72 HTT (0.42) MMP8HTTHPGDPKMMEN1
SCHEMBL13296255 0.72 PKM (0.47) MMP8HTTHPGDPKMMEN1
SCHEMBL28077465 0.72 MEN1 (0.46) MMP8HTTHPGDPKMMEN1
SCHEMBL7781952 0.72 MMP8 (0.50) MMP8HTTHPGDPKMMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6121483-A 3-alkoxypropionic ester derivative, olefin polymerization catalyst, and process for preparation of polyolefin SHOWA DENKO K.K. (JP) 2000-09-19 US disclosed
US-6118019-A 3-alkoxypropionic ester derivative SHOWA DENKO K.K. (JP) 2000-09-12 US disclosed
US-6015867-A MIXTURES OF ORGANOALUMINUM COMPOUNDS, MAGNESIUM, TITANIUM AND HALOGEN COMPOUNDS WITH ELECTRON DONOR ESTER AS INTENSIFIER, NONTOXIC, SAFE, EFFICIENT SHOWA DENKO K.K. (JP) 2000-01-18 US disclosed
EP-0704424-B1 3-Alkoxypropionic ester derivative, olefin polymerization catalyst, and process for preparation of polyolefin SHOWA DENKO KK (JP) 1998-12-30 EP disclosed
EP-0704424-A1 3-alkoxypropionic ester derivative, olefin polymerization catalyst, and process for preparation of polyolefin SHOWA DENKO KABUSHIKI KAISHA (JP) 1996-04-03 EP disclosed