Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 5/20 | 0.89 |
| ▸ | PIM1 | P11309 | 3/20 | 0.89 |
| ▸ | PRKCA | P17252 | 2/20 | 0.68 |
| ▸ | PRKACA | P17612 | 1/20 | 0.68 |
| ▸ | PRKACG | P22612 | 1/20 | 0.68 |
| ▸ | PRKACB | P22694 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CASK | O14936 | 1/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.67 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.67 |
| ▸ | CCNK | O75909 | 1/20 | 0.67 |
| ▸ | STK10 | O94804 | 1/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | PRKCG | P05129 | 1/20 | 0.67 |
| ▸ | PRKCB | P05771 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL29878619 | 1.00 | CAMK2D (0.89) | CAMK2DPIM1PRKCAPRKACAPRKACG | |
| SCHEMBL29438694 | 0.94 | CAMK2D (1.00) | CAMK2DPIM1PRKCAPRKACAPRKACG | |
| SCHEMBL1942352 | 0.94 | CAMK2D (1.00) | CAMK2DPIM1PRKCAPRKACAPRKACG | |
| Hydrochloric Acid SCHEMBL8162861 | 0.93 | CAMK2D (0.98) | CAMK2DPIM1PRKCAPRKACAPRKACG | |
| SCHEMBL8161316 | 0.90 | CAMK2D (0.87) | CAMK2DPIM1PRKCAPRKACAPRKACG | |
| Hydrochloric Acid SCHEMBL8160489 | 0.90 | CAMK2D (0.91) | CAMK2DPIM1PRKCAPRKACAPRKACG | |
| SCHEMBL8154114 | 0.90 | CAMK2D (0.91) | CAMK2DPIM1PRKCAPRKACAPRKACG | |
| Hydrochloric Acid SCHEMBL8163206 | 0.87 | PIM1 (0.86) | CAMK2DPIM1PRKCAPRKACAPRKACG | |
| SCHEMBL30319835 | 0.87 | CAMK2D (0.80) | CAMK2DPIM1PRKCAPRKACAPRKACG | |
| SCHEMBL5683168 | 0.87 | CAMK2D (0.80) | CAMK2DPIM1PRKCAPRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170216360-A1 | METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS | THE GENERAL HOSPITAL CORPORATION | 2017-08-03 | — | — | US | disclosed |
| WO-2015112602-A1 | METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS | SANOFI (FR) | 2015-07-30 | — | — | WO | disclosed |
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170216360-A1 | METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS | CXCL12, VCAM1, ICAM1 | CAMK2D 3114/4885PIM1 1519/4885PRKCA 2452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.