Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ADK | P55263 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HBB | P68871 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CDA | P32320 | 1/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316473 | 1.00 | RAB9A (0.51) | RAB9ALMNAHPGDSMN1; SMN2ADK | |
| SCHEMBL6798816 | 0.75 | MAPT (0.60) | RAB9ALMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6793762 | 0.75 | MAPT (0.60) | RAB9ALMNASMN1; SMN2KDM4EALDH1A1 | |
| Benzoic Acid SCHEMBL6795101 | 0.73 | MAPT (0.51) | RAB9ALMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3603582 | 0.72 | GRM1 (0.59) | RAB9ALMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL5983454 | 0.72 | TYMP (0.73) | RAB9ALMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7615673 | 0.72 | TYMP (0.73) | RAB9ALMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL27732293 | 0.72 | TYMP (0.73) | RAB9ALMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL3610908 | 0.71 | GRM1 (0.61) | RAB9ALMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL8322019 | 0.71 | SMN1; SMN2 (0.51) | RAB9ALMNASMN1; SMN2ADKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137340-A1 | FUSED PYRIMIDINONE COMPOUNDS AS MGLUR LIGANDS | GLATTHAR RALF | 2010-06-03 | — | — | US | disclosed |
| WO-2008107418-A1 | FUSED PYRIMIDINONE COMPOUNDS AS MGLUR LIGANDS | NOVARTIS AG (CH) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137340-A1 | FUSED PYRIMIDINONE COMPOUNDS AS MGLUR LIGANDS | GRM1, GRM2, GRM3 | RAB9A 1068/4885LMNA 4440/4885HPGD 1352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.