SCHEMBL8167160

SCHEMBL8167160

N#CC(C#N)=Cc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.67
MAPT P10636 6/20 0.67
GAA P10253 2/20 0.67
NPC1 O15118 1/20 0.67
RAB9A P51151 1/20 0.67
MAOB P27338 1/20 0.58
KMT2A Q03164 8/20 0.55
MEN1 O00255 7/20 0.55
TDP1 Q9NUW8 2/20 0.55
PKM P14618 2/20 0.55
LMNA P02545 3/20 0.54
CYP1A2 P05177 2/20 0.54
PTGS1 P23219 1/20 0.54
SLC6A2 P23975 1/20 0.54
CYP2C19 P33261 1/20 0.54
PTGS2 P35354 1/20 0.54
SLC6A3 Q01959 1/20 0.54
HIF1A Q16665 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
ALDH1A1 P00352 5/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6949175 0.82 KDM4E (0.61) KDM4EMAPTGAANPC1RAB9A
SCHEMBL6949177 0.82 KDM4E (0.61) KDM4EMAPTGAANPC1RAB9A
SCHEMBL28237091 0.82 KDM4E (0.81) KDM4EMAPTGAANPC1RAB9A
SCHEMBL24845094 0.82 KDM4E (0.81) KDM4EMAPTGAANPC1RAB9A
SCHEMBL2472821 0.80 MAOB (0.57) KDM4EMAPTGAANPC1RAB9A
SCHEMBL12567496 0.79 MAPT (0.52) KDM4EMAPTGAANPC1RAB9A
SCHEMBL18269590 0.79 MAPT (0.51) KDM4EMAPTGAANPC1RAB9A
SCHEMBL6403493 0.79 LMNA (0.59) KDM4EMAPTGAANPC1RAB9A
SCHEMBL10990566 0.79 LMNA (0.59) KDM4EMAPTGAANPC1RAB9A
SCHEMBL7006805 0.79 KDM4E (0.56) KDM4EMAPTGAANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3172272-B1 MODIFIED HETEROPHASIC POLYOLEFIN COMPOSITION MILLIKEN & CO (US) 2020-11-25 EP disclosed
US-9410035-B2 Modified heterophasic polyolefin composition MILLIKEN & COMPANY (US) 2016-08-09 US disclosed
US-20160024289-A1 MODIFIED HETEROPHASIC POLYOLEFIN COMPOSITION MILLIKEN & COMPANY 2016-01-28 US disclosed
US-6030984-A 7-(4-PHENOXYPHENYL)-6-OXOQUINOLIZINES AND DERIVATIVES OF TRICYCLIC RING ANALOGUES, PARTICULARLY 7-OXOTHIENO-(2,3-A)QUINOLIZINE; INHIBITING BETA-AMYLOID PEPTIDE ACTIVITY HOFFMANN-LA ROCHE INC. (US) 2000-02-29 US disclosed
US-5869500-A INHIBITING BETA-AMYLOID PEPTIDE ACTIVITY HOFFMANN-LA ROCHE INC. (US) 1999-02-09 US disclosed
WO-1998025930-A2 USE OF BI- AND TRICYCLIC PYRIDONE DERIVATIVES AGAINST ALZHEIMER'S DISEASE F. HOFFMANN-LA ROCHE AG (CH) 1998-06-18 WO disclosed