Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP11 | Q9NR21 | 10/20 | 0.68 |
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.68 |
| ▸ | GRM5 | P41594 | 5/20 | 0.59 |
| ▸ | PARP1 | P09874 | 3/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | PTPRC | P08575 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18113016 | 0.86 | MAPK1 (0.57) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8151102 | 0.85 | PARP10 (0.70) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8167365 | 0.82 | PARP11 (0.68) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8154134 | 0.82 | PARP11 (0.68) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8155722 | 0.81 | PARP11 (1.00) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8167145 | 0.80 | PARP10 (0.76) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL20294385 | 0.79 | PARP11 (0.72) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8151110 | 0.79 | PARP10 (0.78) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8633556 | 0.78 | HSD17B1 (0.60) | GRM5PARP1PTPRCPTPN1HRH3 | |
| SCHEMBL8163095 | 0.78 | GSK3B (0.74) | PARP11PARP10GRM5PARP1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |