Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13105783 | 0.83 | HPGD (0.51) | HPGDNPSR1MCOLN3ALDH1A1MAPT | |
| SCHEMBL8035994 | 0.79 | NPSR1 (0.54) | HPGDNPSR1MCOLN3ALDH1A1MAPT | |
| SCHEMBL2882577 | 0.79 | NPSR1 (0.54) | HPGDNPSR1MCOLN3ALDH1A1MAPT | |
| SCHEMBL1782141 | 0.79 | SMN1; SMN2 (0.53) | HPGDALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL12988880 | 0.76 | NPSR1 (0.66) | HPGDNPSR1MCOLN3ALDH1A1MAPT | |
| SCHEMBL1827276 | 0.76 | HPGD (0.56) | HPGDNPSR1MCOLN3ALDH1A1MAPT | |
| SCHEMBL2921303 | 0.76 | HPGD (0.56) | HPGDNPSR1MCOLN3ALDH1A1MAPT | |
| SCHEMBL5434766 | 0.76 | CA1 (0.53) | HPGDNPSR1MCOLN3ALDH1A1MAPT | |
| SCHEMBL1825385 | 0.75 | HPGD (0.54) | HPGDNPSR1MCOLN3ALDH1A1MAPT | |
| SCHEMBL2462624 | 0.75 | NPSR1 (0.54) | HPGDNPSR1MCOLN3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156772-A | INDOLE HORMONE INHIBITORS | MERCK & CO., INC. (US) | 2000-12-05 | — | — | US | disclosed |
| US-6077858-A | ADMINISTERING A SUBSTITUTED INDOLE COMPOUND TO THE PATIENTS FOR THE TREATMENT OF A VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |
| US-6004984-A | Antagonists of gonadotropin releasing hormone | MERCK & CO., INC. (US) | 1999-12-21 | — | — | US | disclosed |
| US-5985901-A | TREATMENT OF A VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN | MERCK & CO., INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5981550-A | USEFUL IN TREATING A VARIETY OF SEX-HORMONE RELATED CONDITIONS IN BOTH MEN AND WOMEN, INCLUDING ENDOMETRIOSIS, UTERINE FIBROIDS, POLYCYSTIC OVARIAN DISEASE, HIRSUTISM, PRECOCIOUS PUBERTY, GONADAL STEROID-DEPENDENT NEOPLASIAS | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5756507-A | TREATING SEX HORMONE RELATED DISORDERS | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |