Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.70 |
| ▸ | QPCT | Q16769 | 6/20 | 0.70 |
| ▸ | CDK4 | P11802 | 1/20 | 0.64 |
| ▸ | PRKACA | P17612 | 1/20 | 0.64 |
| ▸ | PRKACG | P22612 | 1/20 | 0.64 |
| ▸ | PRKACB | P22694 | 1/20 | 0.64 |
| ▸ | CCND1 | P24385 | 1/20 | 0.64 |
| ▸ | PRKCB | P05771 | 1/20 | 0.61 |
| ▸ | PRKCA | P17252 | 1/20 | 0.61 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.57 |
| ▸ | IDH1 | O75874 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873644 | 0.88 | PRKACA (0.80) | GSK3BCDK4PRKACAPRKACGPRKACB | |
| SCHEMBL8160483 | 0.85 | GSK3B (0.65) | GSK3BQPCTPRKACAPRKACGPRKACB | |
| SCHEMBL13166904 | 0.84 | CAMK2D (0.78) | GSK3BQPCTCDK4PRKACAPRKACG | |
| SCHEMBL8154930 | 0.83 | GSK3B (0.68) | GSK3BQPCTPRKACAPRKACGPRKACB | |
| SCHEMBL1250687 | 0.82 | GSK3B (0.72) | GSK3BCDK4PRKACAPRKACGPRKACB | |
| SCHEMBL30319781 | 0.82 | GSK3B (0.72) | GSK3BCDK4PRKACAPRKACGPRKACB | |
| SCHEMBL3139598 | 0.82 | GSK3B (0.78) | GSK3BCDK4PRKACAPRKACGPRKACB | |
| SCHEMBL5682666 | 0.81 | GSK3B (0.62) | GSK3BCDK4PRKACAPRKACGPRKACB | |
| SCHEMBL5682520 | 0.81 | GSK3B (0.62) | GSK3BCDK4PRKACAPRKACGPRKACB | |
| SCHEMBL30319769 | 0.81 | GSK3B (0.62) | GSK3BCDK4PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0328026-B1 | SUBSTITUTED PYRROLES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0328026-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1989-08-16 | — | — | EP | disclosed |