Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | PRKCA | P17252 | 2/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154180 | 0.84 | GSK3B (0.76) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL4419603 | 0.82 | GSK3B (0.49) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL8160875 | 0.79 | CCNT1 (0.56) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL6581528 | 0.79 | GSK3B (0.62) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL8161267 | 0.79 | CDK2 (0.56) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL8162060 | 0.78 | CDK2 (0.56) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL8154478 | 0.77 | CDK2 (0.51) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL9667604 | 0.77 | MAPT (0.49) | — | |
| SCHEMBL8161370 | 0.76 | CCNT1 (0.56) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL8161741 | 0.76 | PRKCA (0.56) | GSK3BPRKCACCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0328026-B1 | SUBSTITUTED PYRROLES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0328026-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1989-08-16 | — | — | EP | disclosed |