Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27492040 | 0.87 | HTR2A (0.39) | ALDH1A1MAPTSMN1; SMN2HTR2AHTR2C | |
| SCHEMBL13388545 | 0.82 | MAPT (0.43) | ALDH1A1MAPTHPGDCTNNB1WNT3A | |
| SCHEMBL13388590 | 0.78 | KMT2A (0.47) | ALDH1A1MAPTHPGDPLAUCTNNB1 | |
| SCHEMBL7260687 | 0.76 | SGPL1 (0.37) | ALDH1A1MAPTSMN1; SMN2HPGDHTR2A | |
| SCHEMBL7256224 | 0.76 | SMN1; SMN2 (0.33) | ALDH1A1MAPTSMN1; SMN2HPGDHTR2A | |
| SCHEMBL13388515 | 0.76 | HPGD (0.47) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL6037560 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MAPTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL7261707 | 0.75 | CTSA (0.37) | ALDH1A1SMN1; SMN2HTR2AHTR2CKMT2A | |
| SCHEMBL7255973 | 0.74 | CYP2C9 (0.36) | SMN1; SMN2HTR2AHTR2CKMT2AHTT | |
| SCHEMBL6364181 | 0.72 | POLQ (0.41) | MAPTGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049664-A1 | INHIBITION OF RAF KINASE USING SYMMETRICAL AND UNSYMMETRICAL SUBSTITUTED DIPHENYL UREAS | Bayer Corporation (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999032436-A1 | INHIBITION OF RAF KINASE USING SYMMETRICAL AND UNSYMMETRICAL SUBSTITUTED DIPHENYL UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |