Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL3 | P20749 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804383 | 0.91 | KMT2A (0.46) | BCL3KMT2AJAK1TYK2MAP2K1 | |
| SCHEMBL6036263 | 0.79 | LMNA (0.52) | BCL3LMNA | |
| SCHEMBL6035215 | 0.79 | MAP2K2 (0.56) | BCL3KMT2AMAP2K1MAP2K2HTT | |
| SCHEMBL6035456 | 0.78 | MAP2K1 (0.46) | MAP2K1MAP2K2LMNA | |
| SCHEMBL6035287 | 0.78 | BCL3 (0.59) | BCL3KMT2AJAK1TYK2PDGFRB | |
| SCHEMBL6035847 | 0.77 | NPC1 (0.46) | KMT2AMAP2K1MAP2K2LMNA | |
| SCHEMBL6036153 | 0.77 | MAP2K1 (0.47) | MAP2K1MAP2K2 | |
| SCHEMBL6035749 | 0.77 | MAP2K1 (0.59) | KMT2AMAP2K1MAP2K2PDGFRB | |
| SCHEMBL8169156 | 0.76 | KMT2A (0.56) | BCL3KMT2APDGFRBKITKDR | |
| SCHEMBL6035396 | 0.76 | MAP2K1 (0.47) | KMT2AMAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000037141-A9 | COMBINATION CHEMOTHERAPY | WARNER LAMBERT CO (US) | 2000-12-07 | — | — | WO | disclosed |