Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | HTR1D | P28221 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8168593 | 0.87 | MTNR1A (0.65) | MTNR1AMTNR1B | |
| SCHEMBL8169874 | 0.85 | MTNR1A (0.52) | MTNR1AMTNR1BHTR1AHTR1DHTR2A | |
| SCHEMBL8168177 | 0.85 | MTNR1A (0.52) | MTNR1AMTNR1B | |
| SCHEMBL8161912 | 0.84 | MTNR1A (0.50) | MTNR1AMTNR1B | |
| SCHEMBL8162108 | 0.83 | MTNR1A (0.54) | MTNR1AMTNR1B | |
| SCHEMBL8170080 | 0.81 | MTNR1A (0.78) | MTNR1AMTNR1BHTR1AHTR1DHTR2A | |
| SCHEMBL8168310 | 0.77 | HTR2C (0.57) | MTNR1AMTNR1BHTR1AHTR1DHTR2A | |
| SCHEMBL7797256 | 0.68 | MTNR1A (1.00) | MTNR1AMTNR1BHTR2C | |
| SCHEMBL8162670 | 0.68 | MTNR1A (0.75) | MTNR1AMTNR1BHTR1AHTR1DHTR2A | |
| SCHEMBL6075828 | 0.68 | MTNR1A (0.55) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071946-A | FOR TREATING DISORDERS OF THE MELATONINERGIC SYSTEM, SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-06-06 | — | — | US | disclosed |
| US-5998461-A | SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1999-12-07 | — | — | US | disclosed |