Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 6/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 9/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8172143 | 0.88 | ADRB3 (0.44) | ADRB2ADRB3ADRB1 | |
| SCHEMBL8167993 | 0.83 | ALDH1A1 (0.47) | ADRB2ADRB3ALDH1A1MAPT | |
| SCHEMBL6857917 | 0.83 | CASR (0.62) | ADRB2ADRB3ADRB1ALDH1A1 | |
| SCHEMBL6857912 | 0.83 | CASR (0.62) | ADRB2ADRB3ADRB1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6863062 | 0.82 | CASR (0.61) | ADRB2ADRB3ADRB1ALDH1A1 | |
| SCHEMBL8166640 | 0.80 | ALDH1A1 (0.53) | ALDH1A1 | |
| SCHEMBL8166977 | 0.78 | KCNH2 (0.49) | ADRB2ADRB3ADRB1PLA2G7 | |
| SCHEMBL8165088 | 0.77 | ADRB3 (0.40) | ADRB2ADRB3ADRB1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8159978 | 0.77 | SLC6A2 (0.40) | ADRB2ADRB3ADRB1ALDH1A1 | |
| SCHEMBL7558122 | 0.74 | ALDH1A1 (0.43) | ADRB2ADRB3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | claimed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | claimed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |