SCHEMBL8169154

SCHEMBL8169154

CNCCc1ccc(Br)cc1C

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 6/20 0.53
CHRNB2 P17787 5/20 0.53
CHRNA4 P43681 5/20 0.53
TAAR1 Q96RJ0 6/20 0.52
CHEK1 O14757 1/20 0.43
PYCR1 P32322 1/20 0.42
HTR2A P28223 1/20 0.42
ATM Q13315 1/20 0.36
TP53 P04637 1/20 0.35
CYP1A2 P05177 1/20 0.35
MAPT P10636 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
NFKB1 P19838 1/20 0.35
MAPK1 P28482 1/20 0.35
THPO P40225 1/20 0.35
HIF1A Q16665 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8164579 0.80 SLC6A4 (0.46) CHRNA7CHRNB2CHRNA4TAAR1PYCR1
SCHEMBL29418481 0.80 SLC6A4 (0.46) CHRNA7CHRNB2CHRNA4TAAR1PYCR1
SCHEMBL13359833 0.80 TAAR1 (0.42) TAAR1PYCR1HTR2AATMTP53
SCHEMBL18503575 0.79 TAAR1 (0.56) CHRNA7CHRNB2CHRNA4TAAR1CHEK1
SCHEMBL3857244 0.79 CHRNA7 (0.51) CHRNA7CHRNB2CHRNA4TAAR1CHEK1
SCHEMBL24753988 0.79 PYCR1 (0.39) CHRNA7CHRNB2CHRNA4PYCR1MAPT
SCHEMBL24042054 0.78 TAAR1 (0.41) CHRNA7CHRNB2CHRNA4TAAR1HTR2A
SCHEMBL27755414 0.78 PYCR1 (0.46) PYCR1TP53MAPTMAPK1
SCHEMBL15905723 0.78 PYCR1 (0.46) CHRNA7CHRNB2CHRNA4PYCR1CYP1A2
SCHEMBL8163718 0.77 HTR2A (0.63) CHRNA7CHRNB2CHRNA4TAAR1PYCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021032148-A1 AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF BEIGENE, LTD. (KY) 2021-02-25 WO disclosed
WO-2008079836-A2 MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-07-03 WO disclosed