Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | RARB | P10826 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3334465 | 0.98 | ALDH1A1 (0.57) | ALDH1A1HPGDHSD17B10RARBKEAP1 | |
| SCHEMBL11434203 | 0.85 | ALDH1A1 (0.61) | ALDH1A1HPGDHSD17B10RARBKEAP1 | |
| SCHEMBL11587329 | 0.84 | ALDH1A1 (0.56) | ALDH1A1HPGDHSD17B10RARBPLK1 | |
| SCHEMBL27795532 | 0.83 | CA1 (0.46) | ALDH1A1HPGDHSD17B10RARBPOLB | |
| SCHEMBL26025423 | 0.82 | CA2 (0.48) | ALDH1A1HPGDHSD17B10RARBPLK1 | |
| SCHEMBL13634482 | 0.82 | ALDH1A1 (0.48) | ALDH1A1HPGDKEAP1NFE2L2POLB | |
| SCHEMBL84023 | 0.81 | ALDH1A1 (0.48) | ALDH1A1HPGDHSD17B10RARBTHRB | |
| SCHEMBL3332104 | 0.79 | HPGD (0.43) | ALDH1A1HPGDHSD17B10RARBPOLB | |
| SCHEMBL9169757 | 0.79 | ALDH1A1 (0.60) | ALDH1A1HPGDHSD17B10RARBKDM4E | |
| SCHEMBL9972487 | 0.79 | ALDH1A1 (0.60) | ALDH1A1HPGDHSD17B10RARBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144710-A1 | Piperazine and Piperidine MGLUR5 Potentiators | ASTRAZENECA AB (SE) | 2010-06-10 | — | — | US | disclosed |
| US-20100144710-A1 | Piperazine and Piperidine MGLUR5 Potentiators | ASTRAZENECA AB (SE) | 2010-06-10 | — | — | US | disclosed |
| WO-2008112440-A1 | PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144710-A1 | Piperazine and Piperidine MGLUR5 Potentiators | GRM5, GRM1, GRM2 | ALDH1A1 1506/4885HPGD 2221/4885HSD17B10 3662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.