Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 16/20 | 0.76 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8173300 | 0.94 | MTNR1A (0.78) | MTNR1AMTNR1BHPGDCYP1A2CYP3A4 | |
| SCHEMBL8164780 | 0.91 | MTNR1A (0.70) | MTNR1AMTNR1BHPGDCYP1A2CYP3A4 | |
| SCHEMBL8164776 | 0.89 | MTNR1A (0.62) | MTNR1AMTNR1BHPGDCYP1A2CYP3A4 | |
| SCHEMBL8169118 | 0.89 | MTNR1A (0.80) | MTNR1AMTNR1BHTR2C | |
| SCHEMBL8169375 | 0.87 | MTNR1A (0.77) | MTNR1AMTNR1BHTR2C | |
| SCHEMBL8162658 | 0.86 | MTNR1A (0.80) | MTNR1AMTNR1BHTR2C | |
| SCHEMBL7797256 | 0.86 | MTNR1A (1.00) | MTNR1AMTNR1BHTR2C | |
| SCHEMBL8168555 | 0.84 | MTNR1A (0.73) | MTNR1AMTNR1BHTR2C | |
| SCHEMBL8170080 | 0.83 | MTNR1A (0.78) | MTNR1AMTNR1BHTR2C | |
| SCHEMBL8169275 | 0.83 | MTNR1A (0.71) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071946-A | FOR TREATING DISORDERS OF THE MELATONINERGIC SYSTEM, SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-06-06 | — | — | US | claimed |
| US-6071946-A | FOR TREATING DISORDERS OF THE MELATONINERGIC SYSTEM, SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-06-06 | — | — | US | disclosed |