Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.41 |
| ▸ | GLRB | P48167 | 1/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8507210 | 0.98 | LMNA (0.44) | LMNARECQLGAAALDH1A1TDP1 | |
| SCHEMBL8768105 | 0.83 | HSP90AA1 (0.49) | LMNAALDH1A1TYRHTT | |
| SCHEMBL8608128 | 0.82 | ALOX5 (0.45) | LMNARECQLGAAALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL8506619 | 0.81 | HSP90AA1 (0.48) | LMNAALDH1A1TYRHTT | |
| SCHEMBL6960979 | 0.80 | GAA (0.61) | LMNARECQLGAAALDH1A1TDP1 | |
| SCHEMBL8168277 | 0.79 | HDAC3 (0.46) | GAAALDH1A1TDP1CA2CA1 | |
| SCHEMBL1708401 | 0.79 | GAA (0.58) | LMNARECQLGAAALDH1A1TDP1 | |
| SCHEMBL12324390 | 0.78 | GAA (0.53) | LMNARECQLGAAALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL8505491 | 0.78 | HDAC3 (0.45) | GAAALDH1A1TDP1CA2CA1 | |
| SCHEMBL27277330 | 0.78 | LMNA (0.46) | LMNARECQLGAAALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114393-A | ADMINISTERING A BENZOYLGUANIDINE COMPOUND ANTIPROTOZOA AGENT | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-09-05 | — | — | US | claimed |
| EP-0901788-A2 | Use of inhibitors of the sodium hydrogen exchange in the manufacture of a medicament | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-17 | — | — | EP | claimed |
| CN-1244322-C | Use of inhibitors of sodium-hyfrogen exchanger for production of pharmaceutical for treatment of disorders which are caused by protozoa | AVENTIS PHARMA GMBH (DE) | 2006-03-08 | — | — | CN | disclosed |
| US-6114393-A | ADMINISTERING A BENZOYLGUANIDINE COMPOUND ANTIPROTOZOA AGENT | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-09-05 | — | — | US | disclosed |
| EP-0901788-A2 | Use of inhibitors of the sodium hydrogen exchange in the manufacture of a medicament | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-17 | — | — | EP | disclosed |