Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CDC14B | O60729 | 1/20 | 0.36 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5016468 | 0.86 | CYP19A1 (0.47) | PDE4BNPC1RAB9ACYP19A1CYP11B1 | |
| SCHEMBL2556065 | 0.82 | PDE4B (0.43) | PDE4BCYP19A1CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL14308379 | 0.82 | SMN1; SMN2 (0.37) | PDE4BNPC1RAB9AKDM4EPDE4D | |
| SCHEMBL2562661 | 0.82 | PDE4B (0.52) | PDE4BCYP19A1CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL1647979 | 0.82 | MAOA (0.52) | PDE4BNPC1RAB9ACYP19A1CYP11B1 | |
| SCHEMBL6111442 | 0.81 | PDE4B (0.41) | PDE4BDRD1NPC1RAB9ACYP19A1 | |
| SCHEMBL7970312 | 0.80 | PDE4B (0.36) | PDE4BNPC1RAB9APDE4DPDE4A | |
| SCHEMBL2792898 | 0.80 | PDE4A (0.32) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1302395 | 0.78 | PTPN1 (0.44) | RAB9AALDH1A1MAPTPTPN1LMNA | |
| SCHEMBL5022652 | 0.78 | CYP19A1 (0.47) | NPC1RAB9ACYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008065522-A2 | PROCESS FOR THE SYNTHESIS OF 4-DIFLUOROMETHOXY-8-NITRO-1-FORMYL DIBENZO[B,D] FURAN-AN INTERMEDIATE FOR PDE IV INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-06-05 | — | — | WO | disclosed |