Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 8/20 | 0.45 |
| ▸ | TCF7L2 | Q9NQB0 | 8/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180936 | 0.92 | KDM4E (0.46) | SMN1; SMN2KDM4EALDH1A1LMNACTNNB1 | |
| SCHEMBL8170901 | 0.91 | EPHX2 (0.46) | MAPTEPHX2KDM4ECTNNB1TCF7L2 | |
| SCHEMBL8179718 | 0.90 | MAPT (0.46) | SMN1; SMN2MAPTEPHX2KDM4EALDH1A1 | |
| SCHEMBL7012162 | 0.88 | ALDH1A1 (0.44) | SMN1; SMN2MAPTEPHX2KDM4EALDH1A1 | |
| SCHEMBL8180295 | 0.87 | PDE4A (0.49) | SMN1; SMN2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL8179661 | 0.87 | RHOA (0.43) | SMN1; SMN2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL8179618 | 0.86 | PDE4A (0.44) | SMN1; SMN2MAPTEPHX2KDM4EPDE5A | |
| SCHEMBL8179286 | 0.85 | PDE4A (0.57) | SMN1; SMN2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL8177034 | 0.85 | PDE4A (0.64) | SMN1; SMN2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL7012439 | 0.85 | ALDH1A1 (0.43) | SMN1; SMN2MAPTEPHX2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |
| US-5948911-A | Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 1999-09-07 | — | — | US | disclosed |