SCHEMBL8171069

SCHEMBL8171069

Cc1cc(N(Cc2ccccc2)Cc2ccccc2)ccc1C=NN(C)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 9/20 0.46
KMT2A Q03164 9/20 0.46
MAPT P10636 9/20 0.46
TDP1 Q9NUW8 3/20 0.46
CYP2C19 P33261 1/20 0.45
ALDH1A1 P00352 7/20 0.43
SMN1; SMN2 Q16637 6/20 0.43
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
GAA P10253 3/20 0.42
HTT P42858 2/20 0.42
MAPK1 P28482 1/20 0.42
MCL1 Q07820 1/20 0.42
KDM4E B2RXH2 2/20 0.41
POLB P06746 1/20 0.41
NR3C1 P04150 1/20 0.41
G6PC1 P35575 1/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
PKM P14618 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8171068 1.00 MEN1 (0.46) MEN1KMT2AMAPTTDP1CYP2C19
SCHEMBL358635 0.88 MAPT (0.55) MEN1KMT2AMAPTTDP1CYP2C19
SCHEMBL358634 0.88 MAPT (0.55) MEN1KMT2AMAPTTDP1CYP2C19
SCHEMBL9437241 0.87 MAPT (0.56) MEN1KMT2AMAPTCYP2C19ALDH1A1
SCHEMBL9437204 0.87 MAPT (0.56) MEN1KMT2AMAPTCYP2C19ALDH1A1
SCHEMBL1199323 0.77 CYP2C19 (0.53) CYP2C19ALDH1A1NPC1RAB9AMCL1
SCHEMBL14277977 0.77 MAPT (0.42) MEN1KMT2AMAPTTDP1CYP2C19
SCHEMBL12313273 0.75 MAPT (0.53) MEN1KMT2AMAPTTDP1CYP2C19
SCHEMBL28045547 0.75 MAPT (0.55) MEN1KMT2AMAPTTDP1ALDH1A1
SCHEMBL1702571 0.74 MAPT (0.73) MEN1KMT2AMAPTTDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0462406-B1 An electrophotographic photosensitive material NEC CORP (JP) 1994-04-20 EP claimed
US-6156466-A Photoconductor for electrophotography FUJI ELECTRIC CO., LTD. (JP) 2000-12-05 US disclosed
US-4839252-A PHOTOSENSITIVE LAYER OF A BUTADIENE COMPOUND AND HYDRAZONE COMPOUND; SUPRESSING PHOTO DEGRADATION SHINDENGEN ELECTRIC MANUFACTURING CO., LTD (JP) 1989-06-13 US disclosed