Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 16/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 16/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8179370 | 0.92 | CTNNB1 (0.47) | CTNNB1TCF7L2ESR1KDM4EPDE4A | |
| SCHEMBL8178648 | 0.90 | CTNNB1 (0.46) | CTNNB1TCF7L2ESR1KDM4EPOLB | |
| SCHEMBL7013793 | 0.89 | CTNNB1 (0.45) | CTNNB1TCF7L2ESR1 | |
| SCHEMBL8171364 | 0.87 | PDE4A (0.49) | CTNNB1TCF7L2ESR1KDM4EPDE4A | |
| SCHEMBL8180936 | 0.85 | KDM4E (0.46) | CTNNB1TCF7L2KDM4EPOLBMEN1 | |
| SCHEMBL8183548 | 0.85 | PDE4A (0.44) | CTNNB1TCF7L2ESR1KDM4EPDE4A | |
| SCHEMBL7011880 | 0.85 | CTNNB1 (0.45) | CTNNB1TCF7L2ESR1KDM4E | |
| SCHEMBL8177101 | 0.85 | PDE4A (0.57) | CTNNB1TCF7L2ESR1KDM4EMEN1 | |
| SCHEMBL8181031 | 0.85 | PDE4A (0.64) | CTNNB1TCF7L2ESR1KDM4EPOLB | |
| SCHEMBL8172354 | 0.84 | PDE4A (0.46) | CTNNB1TCF7L2KDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |