Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 12/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 12/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185660 | 0.91 | MAPT (0.46) | CTNNB1TCF7L2ALDH1A1ESR1MAPT | |
| SCHEMBL8171920 | 0.90 | CTNNB1 (0.46) | CTNNB1TCF7L2ESR1KDM4EPOLB | |
| SCHEMBL7011880 | 0.89 | CTNNB1 (0.45) | CTNNB1TCF7L2ALDH1A1ESR1KDM4E | |
| SCHEMBL8180344 | 0.88 | SMN1; SMN2 (0.50) | CTNNB1TCF7L2ALDH1A1ESR1KDM4E | |
| SCHEMBL8180303 | 0.87 | ALDH1A1 (0.49) | ALDH1A1ESR1KDM4EPOLBMAPT | |
| SCHEMBL8182163 | 0.86 | ALDH1A1 (0.49) | CTNNB1TCF7L2ALDH1A1RECQLKDM4E | |
| SCHEMBL7013793 | 0.86 | CTNNB1 (0.45) | CTNNB1TCF7L2ESR1 | |
| SCHEMBL8171864 | 0.86 | PDE4A (0.47) | ALDH1A1KDM4EPOLBMAPTRAB9A | |
| SCHEMBL8181129 | 0.86 | PDE4A (0.53) | CTNNB1TCF7L2ALDH1A1KDM4EPOLB | |
| SCHEMBL8170167 | 0.85 | SMN1; SMN2 (0.48) | CTNNB1TCF7L2ALDH1A1RECQLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |