Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.57 |
| ▸ | NAT1 | P18440 | 1/20 | 0.55 |
| ▸ | CDC25B | P30305 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GLS | O94925 | 1/20 | 0.48 |
| ▸ | GLS2 | Q9UI32 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181632 | 0.94 | PIM1 (0.54) | PIM1PIM3PIM2NAT1CDC25B | |
| SCHEMBL8181630 | 0.94 | PIM1 (0.54) | PIM1PIM3PIM2NAT1CDC25B | |
| SCHEMBL13846678 | 0.92 | PIM1 (0.67) | PIM1PIM3PIM2NAT1CDC25B | |
| SCHEMBL22409611 | 0.92 | PIM1 (0.67) | PIM1PIM3PIM2NAT1CDC25B | |
| SCHEMBL22423780 | 0.92 | PIM1 (0.67) | PIM1PIM3PIM2NAT1CDC25B | |
| SCHEMBL1248780 | 0.82 | PIM1 (0.83) | PIM1PIM3PIM2NAT1HPGD | |
| SCHEMBL1248782 | 0.82 | PIM1 (0.83) | PIM1PIM3PIM2NAT1HPGD | |
| SCHEMBL12891790 | 0.82 | PIM1 (0.83) | PIM1PIM3PIM2NAT1HPGD | |
| SCHEMBL8188705 | 0.81 | TDP1 (0.68) | PIM1PIM3PIM2NAT1CDC25B | |
| SCHEMBL8187128 | 0.79 | PIM1 (0.53) | PIM1PIM3PIM2CDC25BHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |