Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.68 |
| ▸ | GSK3B | P49841 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | PNP | P00491 | 1/20 | 0.54 |
| ▸ | CDC25B | P30305 | 1/20 | 0.53 |
| ▸ | MRE11 | P49959 | 1/20 | 0.53 |
| ▸ | NAT1 | P18440 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22409611 | 0.85 | PIM1 (0.67) | HPGDAKR1B1GSK3BRAB9ACDC25B | |
| SCHEMBL22423780 | 0.85 | PIM1 (0.67) | HPGDAKR1B1GSK3BRAB9ACDC25B | |
| SCHEMBL13846678 | 0.85 | PIM1 (0.67) | HPGDAKR1B1GSK3BRAB9ACDC25B | |
| SCHEMBL8172756 | 0.81 | PIM1 (0.57) | HPGDAKR1B1GSK3BCDC25BNAT1 | |
| SCHEMBL12892017 | 0.81 | PIM1 (0.72) | TDP1HPGDGSK3BRAB9AMAPT | |
| SCHEMBL1249305 | 0.81 | PIM1 (0.72) | TDP1HPGDGSK3BRAB9AMAPT | |
| SCHEMBL621991 | 0.81 | TDP1 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| SCHEMBL621990 | 0.81 | TDP1 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| SCHEMBL621989 | 0.81 | TDP1 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| SCHEMBL14381413 | 0.81 | PIM1 (0.55) | TDP1HPGDAKR1B1GSK3BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |