Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.67 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.67 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.67 |
| ▸ | CDC25B | P30305 | 2/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | NAT1 | P18440 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13846678 | 1.00 | PIM1 (0.67) | PIM1PIM2PIM3CDC25BMAPK10 | |
| SCHEMBL22409611 | 1.00 | PIM1 (0.67) | PIM1PIM2PIM3CDC25BMAPK10 | |
| SCHEMBL8172756 | 0.92 | PIM1 (0.57) | PIM1PIM2PIM3CDC25BMAPK10 | |
| SCHEMBL8181630 | 0.86 | PIM1 (0.54) | PIM1PIM2PIM3CDC25BMAPK10 | |
| SCHEMBL8181632 | 0.86 | PIM1 (0.54) | PIM1PIM2PIM3CDC25BMAPK10 | |
| SCHEMBL8188705 | 0.85 | TDP1 (0.68) | PIM1PIM2PIM3CDC25BGSK3B | |
| SCHEMBL8171854 | 0.84 | PIM1 (0.50) | PIM1PIM2PIM3CDC25BMAPK10 | |
| SCHEMBL8187128 | 0.83 | PIM1 (0.53) | PIM1PIM2PIM3CDC25BMAPK10 | |
| SCHEMBL8188811 | 0.83 | PIM1 (0.89) | PIM1PIM2PIM3GSK3BAKR1B1 | |
| SCHEMBL8188808 | 0.83 | PIM1 (0.89) | PIM1PIM2PIM3GSK3BAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161823-B2 | Anticancer 1,3-dioxane-4,6-dione derivatives and method of combinatorial synthesis thereof | NATIONAL GUARD HEALTH AFFAIRS (SA) | 2021-11-02 | — | — | US | disclosed |
| US-20200290975-A1 | ANTICANCER 1,3-DIOXANE-4,6-DIONE DERIVATIVES AND METHOD OF COMBINATORIAL SYNTHESIS THEREOF | NATIONAL GUARD HEALTH AFFAIRS (SA) | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161823-B2 | Anticancer 1,3-dioxane-4,6-dione derivatives and method of combinatorial synthesis thereof | PDK1, PDHA1, PDHA2 | PIM1 38/4885PIM2 132/4885PIM3 134/4885 |
| US-20200290975-A1 | ANTICANCER 1,3-DIOXANE-4,6-DIONE DERIVATIVES AND METHOD OF COMBINATORIAL SYNTHESIS THEREOF | PDK1, PDHA1, PDHA2 | PIM1 38/4885PIM2 132/4885PIM3 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.