Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8172914 | 0.87 | MAPT (0.37) | SMYD2SMN1; SMN2HTTCYP3A4RAB9A | |
| SCHEMBL20680904 | 0.80 | LMNA (0.34) | SMYD2SMN1; SMN2HTTCYP3A4RAB9A | |
| SCHEMBL20680966 | 0.78 | LMNA (0.34) | SMYD2SMN1; SMN2HTTCYP3A4RAB9A | |
| SCHEMBL21962140 | 0.77 | SMN1; SMN2 (0.33) | SMN1; SMN2RAB9A | |
| SCHEMBL23757058 | 0.76 | SMYD2 (0.35) | SMYD2SMN1; SMN2HTTCYP3A4SLC6A3 | |
| SCHEMBL31431749 | 0.76 | SMYD2 (0.33) | SMYD2SMN1; SMN2HTTCYP3A4 | |
| SCHEMBL31431772 | 0.76 | SMYD2 (0.33) | SMYD2SMN1; SMN2HTTCYP3A4 | |
| SCHEMBL23755691 | 0.75 | TAAR1 (0.38) | SMYD2SMN1; SMN2HTTCYP3A4SLC6A3 | |
| SCHEMBL2466725 | 0.74 | PPARA (0.39) | SMYD2SMN1; SMN2HTTCYP3A4 | |
| SCHEMBL15488120 | 0.74 | SMYD2 (0.36) | SMYD2SMN1; SMN2HTTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658539-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | Novartis Inflammasome Research, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| WO-2019023147-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | IFM Tre, Inc. (US) | 2019-01-31 | — | — | WO | disclosed |
| WO-2000018770-A1 | PYRROLOPYRROLONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXO GROUP LIMITED (GB) | 2000-04-06 | — | — | WO | disclosed |