Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.31 |
| ▸ | PARG | Q86W56 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20680904 | 0.85 | LMNA (0.34) | LMNARAB9AHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL8172907 | 0.78 | SMYD2 (0.33) | LMNARAB9AHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL19475467 | 0.75 | PARG (0.34) | ALOX5APFEN1PARG | |
| SCHEMBL20681345 | 0.74 | LOXL2 (0.37) | HTTSMN1; SMN2CYP3A4POLB | |
| SCHEMBL20680986 | 0.73 | ALDH1A1 (0.35) | LMNARAB9ASMN1; SMN2ALDH1A1ALOX5AP | |
| SCHEMBL21583207 | 0.70 | ALDH1A1 (0.37) | LMNARAB9ASMN1; SMN2ALDH1A1ALOX5AP | |
| SCHEMBL1812544 | 0.67 | MMP2 (0.45) | LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8194770 | 0.66 | TAAR1 (0.39) | HTTSMN1; SMN2CYP3A4SMYD2CYP2C19 | |
| SCHEMBL8172914 | 0.66 | MAPT (0.37) | RAB9AHTTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL17784698 | 0.65 | NSD2 (0.40) | ALOX5APFEN1PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658539-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | Novartis Inflammasome Research, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| WO-2019023147-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | IFM Tre, Inc. (US) | 2019-01-31 | — | — | WO | disclosed |