Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178191 | 0.85 | MAOB (0.55) | MAOBNR4A2TNKS2BCHEMAOA | |
| SCHEMBL9738560 | 0.75 | ALDH1A1 (0.38) | KDM1A | |
| SCHEMBL8190357 | 0.73 | MAOB (0.53) | MAOBNR4A2TNKS2CYP4F2CYP4A11 | |
| SCHEMBL8190359 | 0.73 | MAOB (0.53) | MAOBNR4A2TNKS2CYP4F2CYP4A11 | |
| SCHEMBL6583019 | 0.72 | MAOB (0.56) | MAOBNR4A2TNKS2CYP4F2CYP4A11 | |
| SCHEMBL1268719 | 0.72 | MAOB (0.81) | MAOBNR4A2CYP4F2CYP4A11BCHE | |
| SCHEMBL30344886 | 0.70 | MAOB (0.69) | MAOBNR4A2CYP4F2CYP4A11BCHE | |
| SCHEMBL1636426 | 0.70 | BCHE (0.58) | MAOBNR4A2CYP4F2CYP4A11BCHE | |
| SCHEMBL538272 | 0.70 | MAOB (0.69) | MAOBNR4A2CYP4F2CYP4A11BCHE | |
| SCHEMBL6588487 | 0.70 | SPHK1 (0.55) | MAOBNR4A2TNKS2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030984-A | 7-(4-PHENOXYPHENYL)-6-OXOQUINOLIZINES AND DERIVATIVES OF TRICYCLIC RING ANALOGUES, PARTICULARLY 7-OXOTHIENO-(2,3-A)QUINOLIZINE; INHIBITING BETA-AMYLOID PEPTIDE ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |
| US-5869500-A | INHIBITING BETA-AMYLOID PEPTIDE ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1999-02-09 | — | — | US | disclosed |
| WO-1998025930-A2 | USE OF BI- AND TRICYCLIC PYRIDONE DERIVATIVES AGAINST ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 1998-06-18 | — | — | WO | disclosed |