Butamben

Butamben

SCHEMBL81735

CCCCOC(=O)c1ccc(N)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

TRPA1TRPV4

The experimentally established mechanism targets of Butamben. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 1.00
CYP1A2 P05177 4/20 1.00
CYP3A4 P08684 3/20 1.00
TSHR P16473 3/20 1.00
CYP2C19 P33261 2/20 1.00
CYP2C9 P11712 1/20 1.00
PDE4D Q08499 1/20 1.00
NPC1 O15118 2/20 0.87
RAB9A P51151 2/20 0.87
ALDH1A1 P00352 2/20 0.87
MAPT P10636 1/20 0.87
CYP2D6 P10635 3/20 0.77
SCN1A P35498 2/20 0.77
SCN2A Q99250 2/20 0.77
SCN3A Q9NY46 2/20 0.77
CHRM2 P08172 1/20 0.77
HTR1A P08908 1/20 0.77
GAA P10253 1/20 0.77
DRD3 P35462 1/20 0.77
SLC6A3 Q01959 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butamben SCHEMBL27614630 0.98 LMNA (0.97) LMNACYP1A2CYP3A4TSHRCYP2C19
Butamben SCHEMBL28512544 0.98 LMNA (0.97) LMNACYP1A2CYP3A4TSHRCYP2C19
Butamben SCHEMBL9561560 0.95 LMNA (0.90) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL769120 0.95 ALDH1A1 (0.97) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL25012972 0.93 ALDH1A1 (1.00) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL204048 0.93 ALDH1A1 (1.00) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL1265838 0.93 ALDH1A1 (1.00) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL1265146 0.93 ALDH1A1 (1.00) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL3320139 0.93 ALDH1A1 (1.00) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL9068530 0.93 ALDH1A1 (1.00) LMNACYP1A2CYP3A4TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4802 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144801-A1 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING MUSCLE CONDITIONS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2026-05-28 US claimed
US-20260115156-A1 INJECTABLE COMPOSITION INCLUDING HYDROGEL CONTAINING ANESTHETIC AGENT UNIV KOREA RES & BUS FOUND (KR) 2026-04-30 US claimed
EP-4694866-A1 SUSTAINED RELEASE STABLE EMULSION PHARMACEUTICAL FORMULATIONS Insitu Biologics, Inc. (US) 2026-02-18 EP claimed
EP-4436552-B1 GASTRO-RETENTIVE ORAL DOSAGE UNIT CONTAINING A LOCAL ANAESTHETIC OREXA B V (NL) 2026-02-04 EP claimed
US-20260007753-A1 DERMAL SKIN PROTECTANT AND CARRIER INSPIRED MAT STRATEGIES LLC (US) 2026-01-08 US claimed
WO-2025235864-A1 COATED NEEDLE ADMINISTRATION SYSTEMS EVOLUS, INC. (US) 2025-11-13 WO claimed
US-12419959-B2 Dermal skin protectant and carrier Inspired Material Strategies, LLC (US) 2025-09-23 US claimed
US-20250285560-A1 AR MARKER FOR INJECTION NOBLE INTERNATIONAL, LLC 2025-09-11 US claimed
EP-3876904-B1 ORAL MUCOSAL CARRIER AND PROTECTANT INSPIRED MAT STRATEGIES LLC (US) 2025-08-20 EP claimed
EP-3876949-B1 DERMAL SKIN PROTECTANT AND CARRIER INSPIRED MAT STRATEGIES LLC (US) 2025-08-20 EP claimed
EP-0512547-A1 Pain controlling composition and method of preparation Shulman, Morton (US) 1992-11-11 EP claimed
EP-0502119-A1 LIPOSPHERES FOR CONTROLLED DELIVERY OF SUBSTANCES. NOVA PHARM CORP (US) 1992-09-09 EP claimed
WO-1991007171-A1 LIPOSPHERES FOR CONTROLLED DELIVERY OF SUBSTANCES NOVA PHARMACEUTICAL CORPORATION (US) 1991-05-30 WO claimed
EP-0197308-B1 COMPOSITION AND METHOD FOR PRODUCING PROLONGED PAIN RELIEF Shulman, Morton (US) 1991-04-10 EP claimed
US-5002974-A Oil phase with nonionic surfactant, water phase with thickener for emulsions for skin WARNER-LAMBERT CO. (US) 1991-03-26 US claimed
EP-0383481-A2 Anesthetic oral compositions Richardson-Vicks, Inc. (US) 1990-08-22 EP claimed
EP-0336901-A2 Anesthetic skin moisturizing composition and method of preparing same WARNER-LAMBERT COMPANY (US) 1989-10-11 EP claimed
EP-0197308-A2 Composition and method for producing prolonged pain relief Shulman, Morton (US) 1986-10-15 EP claimed
US-4599354-A Composition and method for producing prolonged pain relief LB 1 GROUP INC. 1986-07-08 US claimed
US-4495174-A TIME-RELEASE AGENTS RESEARCH CORPORATION (US) 1985-01-22 US claimed